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The Hardest Problem AI Ever Solved, with Google DeepMind CEO

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Cleo Abram

He solved “the most important unsolved problem in science”…
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Demis Hassabis is a Nobel Prize winner and CEO of Google DeepMind. He is one of the most important people alive on what is quickly becoming the biggest technological advance of our lifetime. Because the biggest way AI is going to impact your life, you can’t see.

It’s not a chatbot or an image generator. It’s the tools he and his team are building that are invisible to you – in new drug design, nuclear fusion, natural disasters detection, quantum computers.

So who Demis is and what he chooses to build matters a lot. And he’s fascinating…

He’s a childhood chess prodigy who at 17 turned down a reportedly million dollar job offer from a gaming company to go to college instead, and then get a PhD in neuroscience. He founded his company DeepMind with a mission to “solve intelligence” – starting with beating video games. He sold that company to Google specifically because they promised to let DeepMind focus on scientific research.

But as this has turned into the most intense technological battle in recent history, Demis is now in charge of much much more. He’s now behind basically everything Google does in AI.

He’s making decisions that affect your life and millions of other lives every single day.

So what is he planning to do with all that power?

My goal is to show you the future Demis Hassabis wants to build, so you can decide for yourself what you think of it.

Welcome to HUGE* Conversations.

This interview was recorded on March 5, 2026 in London.

Chapters
00:00 The AI most likely to save your life
02:04 Who is the man behind Google’s AI?
03:58 The 50-year mystery AI just solved
06:15 The moment that changed everything
12:30 Why every future drug will use AI
16:47 The cutting edge of drug discovery now
19:13 How DNA-editing and AI work together
21:52 “I would have left AI in the lab longer”
25:39 The “Code Red” that changed google
29:16 Move 37: When AI got creative
34:24 Why true intelligence is so hard
37:22 From zero to world champion in 24 hours
43:09 How militaries should use AI
45:40 AI risks nobody talks about
50:13 What humans can do that AI can’t
55:17 The sci-fi future Demis imagines
58:17 What Demis Hassabis wants his legacy to be
1:00:14 How to get “superpowers” with AI
1:01:56 How to prepare for AI
1:04:59 🙂

You can find me on Instagram here: https://www.instagram.com/cleoabram
On TikTok here: https://www.tiktok.com/@cleoabram
Or on Twitter here: https://twitter.com/cleoabram

Bio:
Cleo Abram is an Emmy-nominated independent video journalist. On her show, HUGE* If True, Cleo explores complex technology topics with rigor and optimism, helping her audience understand the world around them and see positive futures they can help build. Before going independent, Cleo was a video producer for Vox. She wrote and directed the Coding and Diamonds episodes of Vox’s Netflix show, Explained. She produced videos for Vox’s popular YouTube channel, was the host and senior producer of Vox’s first ever daily show, Answered, and was co-host and producer of Vox’s YouTube Originals show, Glad You Asked.

Additional reading and watching:
– The Thinking Game (documentary) : https://www.youtube.com/watch?v=d95J8yzvjbQ
– AlphaGo – The Movie (documentary): https://www.youtube.com/watch?v=WXuK6gekU1Y&t=3159s
– Veritasium’s “AlphaFold – The Most Useful Thing AI Has Ever Done”: https://www.youtube.com/watch?v=P_fHJIYENdI&list=WL&index=5&t=74s
– Google DeepMind: The Podcast, “The future of intelligence | Demis Hassabis”: https://www.youtube.com/watch?v=PqVbypvxDto&t=120s
– AlphaGenome Announcement: https://deepmind.google/blog/alphagenome-ai-for-better-understanding-the-genome/
– AlphaFold paper in Nature: https://www.nature.com/articles/s41586-021-03819-2
– Isomorphic Labs: https://www.isomorphiclabs.com/
– Demis’ definition of AGI: https://x.com/demishassabis/status/1925464027213468029
– WeatherLab (interactive site): https://deepmind.google.com/science/weatherlab
-Material Science AI (GNoME): https://deepmind.google/blog/millions-of-new-materials-discovered-with-deep-learning/
– Quantum Computing AI (AlphaQubit): https://blog.google/innovation-and-ai/models-and-research/google-deepmind/alphaqubit-quantum-error-correction/

Vox: https://www.vox.com/authors/cleo-abram
IMDb: https://www.imdb.com/name/nm10108242/

Gear I use:
Camera: Sony A7SIII
Lens: Sony 16–35 mm F2.8 GM
Audio: Sennheiser SK AVX and Zoom H4N Pro

Music: Musicbed, Tom Fox

Follow along for more episodes of HUGE* If True: https://www.youtube.com/cleoabram?sub_confirmation=1

—
Hey, welcome to the joke down low!

What did the robot say to its leader?
“AI, captain!”

Find a way to use “captain” in a comment to let me know you’re a real one who made it to the end of the description 🙂

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35 thoughts on “The Hardest Problem AI Ever Solved, with Google DeepMind CEO”

  11. I went through this exact situation last year. Lost my job to automation. Now I run The Glass Tower full-time to help others navigate this. If I can help even one person prepare, it's worth it.

  13. The sharpest AI question isn’t whether it can solve the hard problem—it’s what happens when it solves it faster than the guardrails can blink. This conversation makes that tension impossible to ignore.

  23. Crazy how at 46:00 he starts talking about AI agents going rogue being a risk in “2-4 years’ time”, meanwhile the Hugging Face incident occurred just a month after this podcast was uploaded

  28. I am EXTREMELY interested in this for my MTHFR gene mutation which makes so many medications useless or even harmful for me- as well as the nature of my chronic debilitating Lyme disease (never treated, body 'cleared'- most doctors refuse to even diagnose me with Lyme disease or take a look at all of the problems it's causing with my fascia nerves, etc.)
    now I've developed horrible anemia, probably from the gene mutation and Lyme combination – red blood cells low count, way too small and way too large- and now, ironically, Alpha Gal meat (mammal byproduct) allergy from ANOTHER tick bite (attached for less than 12 hours). I feel so desperate lol
    I hope they focus on maybe even just one of these issues.

  29. the brain is classical computational until we get into the studies of were memories are stored. And then we find ourselves in the space that brains don't store memories in the ways we could think a pc or phone stores them

  32. Please include a Spanish audio version in all your videos, Cleo.
    CLEO PON LA VERSIÓN DE AUDIO EN ESPAÑOL DE TODOS TUS VIDEOS POR FAVOR 🙏🏻 😭😭😭😭🙏🏻🙏🏻🙏🏻🙏🏻💛💛💛💛

  33. Cleo, inspiring interview, jaw dropping! Demis, just learn about your name and what you are doing. What you were doing is just as important as what Elon Musk is doing for the future of humanity. Thank you thank you thank you!

  34. Just wait till the ultra fast bad technologies start happening and then mix them in with politics like Putin and Trump OMG psychopaths who have no moral backbone

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